This test assesses 13 organic acids in first morning spot urine. Evaluation of cellular energy metabolism related to fatigue and associated symptoms. The reference ranges for this test apply to children (2-12 yrs) and adults.
Optimal health and well-being depends on the healthy functioning of the cell. The
mitochondria of each cell functions as its energy “factory”. The primary function of the
mitochondria is to efficiently produce the energy we require to live vital lives.
The Cellular Energy Profile measures a special grouping of organic acids. These
metabolites primarily reflect:
- Carbohydrate metabolism
- Mitochondrial function
- Oxidation of fatty acids
The organic acids measured in this panel are central components or intermediates in metabolic pathways of energy conversion related to the Krebs (citric acid) cycle. This means that they are essential in the production of ATP, the cell’s main fuel source.
Defects of mitochondrial metabolism are associated with a wide spectrum of illness and disease. This test can reveal metabolic distress that can arise from many causes, including:
- Toxic exposure
- Nutrient deficiency
- Intestinal dysbiosis
- Oxidative stress
- Poor diet
The Cellular Energy Profile is particularly relevant for the chronically “unwell” patient who may be experiencing:
- Multiple chemical sensitivities
- Hypotonia (loss of muscle tone)
- pH imbalances
- Low exercise tolerance
- Muscle/joint pain
Organic acids also play a pivotal role in generating energy for muscle tissue. For this reason, mitochondrial defects are associated with a variety of neuromuscular disorders. Imbalances may also influence cardiac function, glycemic control and behavior.
Mitochondria modulate cell death, therefore their dysfunction is closely linked with the aging process and neurodegenerative diseases like:
- Alzheimer’s disease
- Parkinson’s disease
- Amyotrophic Lateral Sclerosis (ALS)
Organic Acid Testing
- The test serves as a diagnostic aid for acquired, as opposed to in-born, errors of organic acid metabolism.
- Reference ranges are available for adults and for children aged 2 to 12 years.
- Each analyte is reported in relation to creatinine levels to ensure normal renal function and representative results.
- Significantly abnormal findings may be due to inborn errors if they persist after removal of toxins, nutrient supplementation, dietary adjustments and correction of intestinal dysbiosis or infection. For these cases, further specialised follow-up testing is
needed to identify congenital organic acidopathies